Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'RxODE' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: |
2.0.7 |
| Depends: |
R (≥ 4.0) |
| Imports: |
Rcpp (≥ 0.12.3), brew, parallel, lbfgsb3c, dparser, methods, ggplot2, rex, minqa, Matrix, n1qn1 (≥ 6.0.1-10), fastGHQuad, RxODE (≥ 1.1.5), nlme, magrittr, backports, symengine |
| LinkingTo: |
dparser (≥ 0.1.8), RxODE (≥ 1.0.0-0), RcppEigen (≥
0.3.3.3.0), lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0), RcppArmadillo (≥ 0.5.600.2.0) |
| Suggests: |
Deriv, Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dotwhisker, dplyr, expm, flextable, ggtext, patchwork, gridExtra, huxtable, lattice, lbfgs, lotri, madness, matrixcalc, nloptr, officer, pkgdown, reshape2, rmarkdown, testthat, tidyr, ucminf, vpc (≥ 1.1.0), xgxr, yaml, xpose, generics, tibble, checkmate, cli, qs, covr, forecast, latticeExtra |
| Published: |
2022-03-27 |
| Author: |
Matthew Fidler 
[aut],
Yuan Xiong [aut],
Rik Schoemaker
[aut],
Justin Wilkins
[aut],
Wenping Wang [aut, cre],
Robert Leary [ctb],
Mason McComb
[aut],
Vipul Mann [aut],
Mirjam Trame [ctb],
Teun Post [ctb],
Richard Hooijmaijers [aut],
Hadley Wickham [ctb],
Dirk Eddelbuettel [cph],
Johannes Pfeifer [ctb],
Robert B. Schnabel [ctb],
Elizabeth Eskow [ctb],
Emmanuelle Comets [ctb],
Audrey Lavenu [ctb],
Marc Lavielle [ctb],
David Ardia [cph],
Katharine Mullen [cph],
Ben Goodrich [ctb] |
| Maintainer: |
Wenping Wang <wwang8198 at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: |
https://github.com/nlmixrdevelopment/nlmixr |
| NeedsCompilation: |
yes |
| Citation: |
nlmixr citation info |
| Materials: |
NEWS |
| In views: |
DifferentialEquations, Pharmacokinetics |
| CRAN checks: |
nlmixr results |