Antibody levels measured in a (cross–sectional) population sample can be translated into an estimate of the frequency with which seroconversions (infections) occur in the sampled population. Formulated simply: the presence of many high titres indicates that many subjects likely experienced infection recently, while low titres indicate a low frequency of infections in the sampled population.
The seroincidence calculator script was designed to use the longitudinal response characteristics by means of a set of parameters characterizing the longitudinal response of the selected serum antibodies.